abstract：:Even though lysophospholipids have attracted much interest in recent years on account of their unique bioactivity, research related to lysophospholipids is usually hampered by problems associated with standard sample preparation and discrimination of regioisomers. Herein, we demonstrate a quick tin-chemistry-based syn...

journal_title：Chemistry and physics of lipids

authors： Furukawa T,Fuda H,Miyanaga S,Watanabe C,Chiba H,Hui SP

更新日期：2016-10-01 00:00:00

abstract：:Ceramide-1-phosphate (C1P) is an important signaling sphingolipid and a metabolite of ceramide. C1P contains an anionic phosphomonoester head group and has been shown to regulate physiological and pathophysiological processes such as cell proliferation, inflammation, apoptosis, phagocytosis, and macrophage chemotaxis....

journal_title：Chemistry and physics of lipids

authors： Shirey CM,Ward KE,Stahelin RV

更新日期：2016-10-01 00:00:00

abstract：:Applications of solid-state NMR spectroscopy for investigating the influences of lipid-cholesterol interactions on membrane fluctuations are reviewed in this paper. Emphasis is placed on understanding the energy landscapes and fluctuations at an emergent atomistic level. Solid-state (2)H NMR spectroscopy directly meas...

journal_title：Chemistry and physics of lipids

authors： Molugu TR,Brown MF

更新日期：2016-09-01 00:00:00

abstract：:Cholesterol has limited solubility in phospholipid bilayers. The solubility limit is strongly dependent on the nature of the lipid with which the cholesterol is mixed while properties of the crystals formed can be modified by phospholipid-cholesterol interactions. In this review we summarize the various methods that h...

journal_title：Chemistry and physics of lipids

authors： Epand RM,Bach D,Wachtel E

更新日期：2016-09-01 00:00:00

abstract：:To exploit the potential of Didodecyldimethylammonium bromide (D12DAB) as a core lipidic constituent, an attempt was made to fabricate and optimize cationic nanostructured lipid carriers (cNLCs) using a cost-effective microemulsification methodology. Designed composition was optimized by studying the effect of differe...

journal_title：Chemistry and physics of lipids

authors： Kanwar R,Kaur G,Mehta SK

更新日期：2016-03-01 00:00:00

abstract：:The role of membrane cholesterol as a crucial regulator in the structure and function of membrane proteins and receptors is well documented. However, there is a lack of consensus on the mechanism for such regulation. We have previously shown that the function of an important neuronal receptor, the serotonin1A receptor...

journal_title：Chemistry and physics of lipids

authors： Pal S,Chakraborty H,Bandari S,Yahioglu G,Suhling K,Chattopadhyay A

更新日期：2016-03-01 00:00:00

abstract：:Oral administration is the most convenient way of all the drug delivery routes. Orally administered bioactive compounds must resist the harsh acidic fluids or enzyme digestion in stomach, to reach their absorbed destination in small intestine. This is the case for silibinin, a drug used to protect liver cells against ...

journal_title：Chemistry and physics of lipids

authors： Zhao T,Maniglio D,Chen J,Chen B,Migliaresi C

更新日期：2016-03-01 00:00:00

abstract：:Caged ceramide analogues (C6-, C16-, C18-, C22- and C24-Cer) have been prepared by introducing a hydrophilic coumarin-based cage bearing a short polyethylene glycol (PEG) chain. (6-Bromo-7-mTEGylated-coumarin-4-yl)methyl (Btc) caged ceramide showed efficient photo-uncaging to release the parent ceramide upon direct ex...

journal_title：Chemistry and physics of lipids

authors： Kim YA,Day J,Lirette CA,Costain WJ,Johnston LJ,Bittman R

更新日期：2016-01-01 00:00:00

abstract：:Lipids have a variety of physiological roles, ranging from structural and biophysical contributions to membrane functions to signaling contributions in normal and abnormal physiology. This review highlights some of the contributions made by Robert Bittman to our understanding of lipid assemblies through the production...

journal_title：Chemistry and physics of lipids

authors： Parrill AL

更新日期：2016-01-01 00:00:00

abstract：:Cardiolipin (CL) is a phospholipid with many unique characteristics. CL is synthesized in the mitochondria and resides almost exclusively within the mitochondrial inner membrane. Unlike most phospholipids that have two fatty acyl chains, CL possesses four fatty acyl chains resulting in unique biophysical characteristi...

journal_title：Chemistry and physics of lipids

authors： Gaspard GJ,McMaster CR

更新日期：2015-12-01 00:00:00

abstract：:We performed differential scanning calorimetric (DSC) and Fourier transform infrared (FTIR) spectroscopic studies of the effects of cholesterol (CHOL), 7-dehydrocholeterol (7DHC) and desmosterol (DES) on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine (DPPC) bilayer membranes. 7DHC a...

journal_title：Chemistry and physics of lipids

authors： Benesch MG,Lewis RN,McElhaney RN

更新日期：2015-10-01 00:00:00

abstract：:We present the results of a comparative differential calorimetric and Fourier transform infrared spectroscopic study of the effect of cholesterol and five analogues on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes. These sterols/steroids differ in both the nature...

journal_title：Chemistry and physics of lipids

authors： Benesch MG,Lewis RN,Mannock DA,McElhaney RN

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to develop, optimize and evaluate the potential of solid lipid nanoparticles (SLNs) as a topical delivery system for targeted and prolonged release of Fluocinolone acetonide (FA). FA loaded SLNs were successfully developed by an emulsification-ultrasonication method and optimized using 17-run...

journal_title：Chemistry and physics of lipids

authors： Pradhan M,Singh D,Singh MR

更新日期：2015-02-01 00:00:00

abstract：:The development of "molecular rulers" would allow one to quantitatively locate the penetration depth of intercalants within lipid bilayers. To this end, an attempt was made to correlate the (13)C NMR chemical shift of polarizable "reporter" carbons (e.g., carbonyls) of intercalants within DMPC liposomal bilayers - wit...

journal_title：Chemistry and physics of lipids

authors： Afri M,Alexenberg C,Aped P,Bodner E,Cohen S,Ejgenburg M,Eliyahu S,Gilinsky-Sharon P,Harel Y,Naqqash ME,Porat H,Ranz A,Frimer AA

更新日期：2014-12-01 00:00:00

abstract：:In this work we studied a binary lipid matrix of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (POPG), a composition that mimics the inner membrane of Escherichia coli. More specifically, liposomes with varying fractions of POPG were analys...

journal_title：Chemistry and physics of lipids

authors： Suárez-Germà C,Morros A,Montero MT,Hernández-Borrell J,Domènech Ò

更新日期：2014-10-01 00:00:00

abstract：:Trehalose lipids are bacterial biosurfactants which present interesting physicochemical and biological properties. These glycolipids have a number of different commercial applications and there is an increasing interest in their use as therapeutic agents. The amphiphilic nature of trehalose lipids points to the membra...

journal_title：Chemistry and physics of lipids

authors： Teruel JA,Ortiz A,Aranda FJ

更新日期：2014-07-01 00:00:00

abstract：:Besides their conventional role as energy suppliers for the cell, mitochondria in vertebrates are active regulators of apoptosis. They release apoptotic factors from the intermembrane space into the cytosol through a mechanism that involves the Bcl-2 protein family, mediating permeabilization of the outer mitochondria...

journal_title：Chemistry and physics of lipids

authors： Cosentino K,García-Sáez AJ

更新日期：2014-07-01 00:00:00

abstract：:Cardiolipin is a major phospholipid in mitochondria and is involved in the generation of cellular energy in the form of ATP. In mammalian and eukaryotic cells it is synthesized via the cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol phosphate pathway. This brief review will describe some of the more recent studies on m...

journal_title：Chemistry and physics of lipids

authors： Mejia EM,Nguyen H,Hatch GM

更新日期：2014-04-01 00:00:00

abstract：:Historically, cellular trafficking of lipids has received much less attention than protein trafficking, mostly because its biological importance was underestimated, involved sorting and translocation mechanisms were not known, and analytical tools were limiting. This has changed during the last decade, and we discuss ...

journal_title：Chemistry and physics of lipids

authors： Schlattner U,Tokarska-Schlattner M,Rousseau D,Boissan M,Mannella C,Epand R,Lacombe ML

更新日期：2014-04-01 00:00:00

abstract：:Cardiolipins (CLs) are ancient and unusual dimeric phospholipids localized in the plasma membrane of bacteria and in the inner mitochondrial membrane of eukaryotes. In mitochondria, two types of asymmetries--trans-membrane and molecular--are essential determinants of CL functions. In this review, we describe CL-based ...

journal_title：Chemistry and physics of lipids

authors： Kagan VE,Chu CT,Tyurina YY,Cheikhi A,Bayir H

更新日期：2014-04-01 00:00:00

abstract：:Cardiolipins (CLs) are important biologically for their unique role in biomembranes that couple phosphorylation and electron transport like bacterial plasma membranes, chromatophores, chloroplasts and mitochondria. CLs are often tightly coupled to proteins involved in oxidative phosphorylation. The first step in under...

journal_title：Chemistry and physics of lipids

authors： Boscia AL,Treece BW,Mohammadyani D,Klein-Seetharaman J,Braun AR,Wassenaar TA,Klösgen B,Tristram-Nagle S

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:In this study, we aimed to compare the serum lipid profile and fatty acid (FA) compositions of erythrocyte membrane (EM) and plasma in three different patient groups (group 1: type 2 diabetes mellitus (T2DM)+end-stage renal disease (ESRD), group 2: ESRD, group 4: T2DM) and healthy controls (group 3) simultan...

journal_title：Chemistry and physics of lipids

authors： Sertoglu E,Kurt I,Tapan S,Uyanik M,Serdar MA,Kayadibi H,El-Fawaeir S

更新日期：2014-02-01 00:00:00

abstract：:We examine the effects of cholesterol (Chol) on the mechanical properties of membranes consisting of 16:0/18:1 POPC lipid and of lipids with conjugated linoleic acid (CLA), cis-9/trans-11 CLA (C9T11) and trans-10/cis-12 CLA (T10C12). Atomistic molecular dynamics (MD) simulations of POPC-Chol and CLA-Chol mixtures at v...

journal_title：Chemistry and physics of lipids

authors： Khelashvili G,Johner N,Zhao G,Harries D,Scott HL

更新日期：2014-02-01 00:00:00

abstract：:Under condition of ROS formation in lipid membranes, free radical reactions can proceed in both hydrophobic (peroxidation of lipids, POL) and polar (free radical fragmentation) parts of the bilayer. Free-radical fragmentation is typical for the lipids containing a hydroxyl group in β-position with respect to an ester ...

journal_title：Chemistry and physics of lipids

authors： Olshyk VN,Melsitova IV,Yurkova IL

更新日期：2014-01-01 00:00:00

abstract：:Sphingolipids are recognized as signaling mediators in a growing number of pathways, and represent potential targets to address many diseases. The study of sphingolipid signaling in yeast has created a number of breakthroughs in the field, and has the potential to lead future advances. The aim of this article is to pr...

journal_title：Chemistry and physics of lipids

authors： Montefusco DJ,Matmati N,Hannun YA

更新日期：2014-01-01 00:00:00

abstract：:Lipids play an important role in the maturation, viability and function of sperm cells. In this study, we examined the neutral and polar lipid composition of boar spermatozoa by thin-layer chromatography/mass spectrometry. Main representatives of the neutral lipid classes were diacylglycerols containing saturated (myr...

journal_title：Chemistry and physics of lipids

authors： Svetlichnyy V,Müller P,Pomorski TG,Schulze M,Schiller J,Müller K

更新日期：2014-01-01 00:00:00

abstract：:The chloroplast twin arginine translocation system transports highly folded precursor proteins across the thylakoid using the protonmotive force as its only energy source. Hcf106 and another thylakoid protein, cpTatC compose the precursor receptor complex. Hcf106 is predicted to contain a single amino terminal transme...

journal_title：Chemistry and physics of lipids

authors： Zhang L,Liu L,Maltsev S,Lorigan GA,Dabney-Smith C

更新日期：2013-10-01 00:00:00

abstract：:Prion diseases are fatal neurodegenerative disorders affecting many mammals, ovine scrapie being the archetypal prion disease. Several independent studies in murine and cell-based models of scrapie have highlighted the presence of a link between prion generation and lipid alterations; yet, no data on natural disease a...

journal_title：Chemistry and physics of lipids

authors： Rosa A,Scano P,Incani A,Pilla F,Maestrale C,Manca M,Ligios C,Pani A

更新日期：2013-10-01 00:00:00

abstract：:Phosphatidylserine (PS) is an aminophospholipid that is prone to glycation. In oxidative conditions, glycated PS may lead to the formation of Amadori compounds and advanced glycated end products (AGEs), which are known to accumulate in diabetic patients. Nevertheless, there have been no studies that identified product...

journal_title：Chemistry and physics of lipids

authors： Maciel E,da Silva RN,Simões C,Melo T,Ferreira R,Domingues P,Domingues MR

更新日期：2013-09-01 00:00:00

abstract：:The synthesis and self-assembling properties of a model compound in a new class of cationic phospholipids with a highly unsaturated conjugated fatty acid are described. In addition, the potential of this new lipid as a nucleic acid carrier was evaluated through lipoplex formulations employing 1,2-dioleoyl-sn-glycero-3...

journal_title：Chemistry and physics of lipids

authors： Øpstad CL,Sliwka HR,Partali V,Elgsaeter A,Leopold P,Jubeli E,Khalique NA,Raju L,Pungente MD

更新日期：2013-05-01 00:00:00

abstract：:The cell plasma membrane is a complex system, which is thought to be capable of exhibiting non-random lateral organization. Studies of live cells and model membranes have yielded mechanisms responsible for the formation, growth, and maintenance of nanoscopic heterogeneities, although the existence and mechanisms that ...

journal_title：Chemistry and physics of lipids

authors： Pan J,Heberle FA,Petruzielo RS,Katsaras J

更新日期：2013-05-01 00:00:00

abstract：:The MARTINI coarse-grained model is used to gain insight into the association of WALP23 helices in three different lipid membranes: DMPC, DPPC and DOPC. Potentials of mean force describing the association of two WALP23 helices embedded in different lipid bilayers indicate no barrier of association and a stabilization ...

journal_title：Chemistry and physics of lipids

authors： Castillo N,Monticelli L,Barnoud J,Tieleman DP

更新日期：2013-04-01 00:00:00

abstract：:Recent studies have revealed that sphingomyelin (SM) is involved in metabolic syndrome and is a new target of an anti-metabolic syndrome drug. Deficiencies in the enzyme SM synthase 1 (SMS1) result in severe abnormalities, whereas deficiencies in SMS2 do not. SMS1 and SMS2 synthesize SM under similar conditions, so th...

journal_title：Chemistry and physics of lipids

authors： Zama K,Mitsutake S,Watanabe K,Okazaki T,Igarashi Y

更新日期：2012-10-01 00:00:00

abstract：:The decomposition of hydrogen peroxide catalyzed by catalase entrapped in the pool of dipalmitoylphosphatidyl choline unilamellar liposomes has been studied. The rate of the process was evaluated by following the production of oxygen as a function of time. Under the experimental conditions employed the rate of oxygen ...

journal_title：Chemistry and physics of lipids

authors： Abuin E,Lissi E,Ahumada M

更新日期：2012-09-01 00:00:00

abstract：:The 3-sulfates of the S-acyl glutathione (GSH) conjugates of five natural bile acids (cholic, chenodeoxycholic, deoxycholic, ursodeoxycholic, and lithocholic) were synthesized as reference standards in order to investigate their possible formation by a rat liver cytosolic fraction. Their structures were confirmed by p...

journal_title：Chemistry and physics of lipids

authors： Mitamura K,Hori N,Mino S,Iida T,Hofmann AF,Ikegawa S

更新日期：2012-04-01 00:00:00

abstract：:A detailed understanding of biomembrane architecture is still a challenging task. Many in vitro studies have shown lipid domains but much less information is known about the lateral organization of membrane proteins because their hydrophobic nature limits the use of many experimental methods. We examined lipid domain ...

journal_title：Chemistry and physics of lipids

authors： Gröger T,Nathoo S,Ku T,Sikora C,Turner RJ,Prenner EJ

更新日期：2012-02-01 00:00:00

abstract：:Ceriporiopsis subvermispora is a selective white-rot fungus that secretes alk(en)ylitaconic acids named ceriporic acids, known as ion redox silencers. In this study, we analysed a series of extracellular lipid-related metabolites produced by the fungus and found that a wide variety of ceriporic acids and fatty acids, ...

journal_title：Chemistry and physics of lipids

authors： Nishimura H,Murayama K,Watanabe T,Honda Y,Watanabe T

更新日期：2012-01-01 00:00:00

abstract：:Arginine-rich peptides receive increased attention due to their capacity to cross different types of membranes and to transport cargo molecules inside cells. Even though peptide-induced destabilization has been investigated extensively, little is known about the peptide side-chain and backbone orientation with respect...

journal_title：Chemistry and physics of lipids

authors： Bouchet AM,Lairion F,Ruysschaert JM,Lensink MF

更新日期：2012-01-01 00:00:00

abstract：:The aim of these works present in this paper consisted in the development and evaluation of quantitative structure property models (QSPR) for the prediction of the melting points of a series constituted by 62 fatty acids. The best multilinear regressions method (MLR) is used to develop models for the prediction of the...

journal_title：Chemistry and physics of lipids

authors： Guendouzi A,Mekelleche SM

更新日期：2012-01-01 00:00:00

abstract：:Melatonin and its structural analogues display antioxidant activity in vivo but their activity in model membranes is not very well known. In this study, we have investigated the antioxidant capacity of melatonin and structural analogues on Fe(2+)-initiated peroxidation of sonicated liposomes made of retinal lipids. Th...

journal_title：Chemistry and physics of lipids

authors： Fagali N,Catalá A

更新日期：2011-10-01 00:00:00